In this three-year project, we will develop a network-based software platform for dynamic and explorative analysis of of the CHRIS cohort data. The project will be carried out in collaboration with TUM, Eurac Research, and UNIBZ.
Together with partners from TUM and University of Hamburg, we will develop dimensionality reduction techniques for scRNA-seq data based on inference of differential gene regulatory network. The new methods will be used to investigate CD4 helper T cell exhaustion, a limiting factor in immunotherapy.
DIGEST is a systems medicine tool for the in silico validation of gene and disease sets, clusterings, and subnetworks w.r.t. genetic and functional coherence. It is available as a web service, as a Python package, and via a REST API.
We are happy to announce that our paper on how to use enumeration of diverse minimum-cost perfect and error-correcting bipartite matchings for robust data matching has been published in Information Sciences.