Journal Articles
- , , , , , :
SwitchTFI: identifying transcription factors driving cell differentiation
In: Genome Biology 26 (2025), Article No.: 410
ISSN: 1474-7596
DOI: 10.1186/s13059-025-03876-0 - , , , , , , , , , , , , , :
3D Tumor microenvironment interaction reveals AP-1 complex regulation and contact-mediated reprogramming of bone marrow stromal cells in chronic lymphocytic leukemia
In: HemaSphere 9 (2025), Article No.: e70199
ISSN: 2572-9241
DOI: 10.1002/hem3.70199 - , , , , , , , , :
Cellular morphodynamics as quantifiers for functional states of resident tissue macrophages in vivo
In: PLoS Computational Biology 21 (2025), Article No.: e1011859
ISSN: 1553-734X
DOI: 10.1371/journal.pcbi.1011859 - , , :
Feature graphs for interpretable unsupervised tree ensembles: centrality, interaction, and application in disease subtyping
In: BioData Mining 18 (2025), Article No.: 15
ISSN: 1756-0381
DOI: 10.1186/s13040-025-00430-3 - , , , , , , , , , , , , , , , , , , , , , :
Comparison of the safety profiles of CD19-targeting CAR T-cell therapy in patients with SLE and B-cell lymphoma
In: Blood (2025)
ISSN: 0006-4971
DOI: 10.1182/blood.2025028375 - , , :
Data splitting to avoid information leakage with DataSAIL
In: Nature Communications 16 (2025), Article No.: 3337
ISSN: 2041-1723
DOI: 10.1038/s41467-025-58606-8 - , , , , :
Deep learning models for unbiased sequence-based PPI prediction plateau at an accuracy of 0.65
In: Bioinformatics 41 (2025), p. i590-i598
ISSN: 1367-4803
DOI: 10.1093/bioinformatics/btaf192 - , , , :
Identification of transcriptional regulators using a combined disease module identification and prize-collecting Steiner tree approach
In: Network and Systems Medicine 1 (2025), p. 42-56
ISSN: 2941-251X
DOI: 10.14293/NSM.25.1.0003 - , , , :
Inference of differential kinase interaction networks with KINference
In: Bioinformatics 41 (2025), Article No.: btaf349
ISSN: 1367-4803
DOI: 10.1093/bioinformatics/btaf349 - , , , , :
NApy: efficient statistics in Python for large-scale heterogeneous data with enhanced support for missing data
In: GigaScience 14 (2025), Article No.: giaf140
ISSN: 2047-217X
DOI: 10.1093/gigascience/giaf140 - , , , , , , , , :
Novel co-culture model of T cells and midbrain organoids for investigating neurodegeneration in Parkinson’s disease
In: npj Parkinson’s Disease 11 (2025), Article No.: 36
ISSN: 2373-8057
DOI: 10.1038/s41531-025-00882-8
Conference Contributions
- , , , , , , , , , :
Machine Learning-Based Depression Detection Using Physiological Signals and Smartphone-Based Behavioral Interventions
18th International Congress of Behavioral Medicine (ICBM 2025) (Vienna, 06/08/2025 - 09/08/2025)
In: ICBM, INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE: 2025 - , , , , , :
A Differentiable Approximation of the Graph Edit Distance
In: Andrea Torsello, Luca Rossi, Luca Cosmo, Giorgia Minello (ed.): Joint IAPR International Workshops on Statistical Techniques in Pattern Recognition and Structural and Syntactic Pattern Recognition, S+SSPR 2024, Cham: 2025
DOI: 10.1007/978-3-031-80507-3_1 - , , , , , , , , , :
EmpkinS-EKSpression: Results from a Randomized-Controlled Clinical Trial on the Effects of a Facial Expression-based Training for Cognitive Restructuring
EACLIPT (Frankfurt, 28/05/2025 - 30/05/2025) - , :
Gene Co-expression Networks are Poor Proxies for Expert-Curated Gene Regulatory Networks
In: Luc Brun, Vincenzo Carletti, Sébastien Bougleux, Benoît Gaüzère (ed.): Graph-Based Representations in Pattern Recognition. GbRPR 2025., Cham: 2025
DOI: 10.1007/978-3-031-94139-9_4
Journal Articles
- , , , , , , , , , , , :
Correction to: The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D (Acta Neuropathologica Communications, (2023), 11, 1, (129), 10.1186/s40478-023-01618-6)
In: Acta Neuropathologica Communications 12 (2024), Article No.: 49
ISSN: 2051-5960
DOI: 10.1186/s40478-024-01752-9 - , , , :
A Transfer Learning-Based Framework for Classifying Lymph Node Metastasis in Prostate Cancer Patients
In: Biomedicines 12 (2024), Article No.: 2345
ISSN: 2227-9059
DOI: 10.3390/biomedicines12102345 - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , :
Network medicine-based epistasis detection in complex diseases: Ready for quantum computing
In: Nucleic Acids Research 52 (2024), p. 10144-10160
ISSN: 0305-1048
DOI: 10.1093/nar/gkae697 - , , , , , , , , , , , , :
Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil
In: Genome Research 34 (2024), p. 1355-1364
ISSN: 1088-9051
DOI: 10.1101/gr.279123.124 - , , , , , , :
Guiding questions to avoid data leakage in biological machine learning applications
In: Nature Methods 21 (2024), p. 1444-1453
ISSN: 1548-7091
DOI: 10.1038/s41592-024-02362-y - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , :
Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing
In: Nucleic Acids Research 52 (2024), p. W481-W488
ISSN: 0305-1048
DOI: 10.1093/nar/gkae388 - , , , , , , , , , :
Single-Cell Multi-Omics Map of Cell Type-Specific Mechanistic Drivers of Multiple Sclerosis Lesions
In: Neurology, Neuroimmunology and Neuroinflammation 11 (2024), p. e200213-
ISSN: 2332-7812
DOI: 10.1212/NXI.0000000000200213 - , , :
Cracking the black box of deep sequence-based protein-protein interaction prediction
In: Briefings in Bioinformatics 25 (2024), Article No.: bbae076
ISSN: 1467-5463
DOI: 10.1093/bib/bbae076 - , , , , , :
DysRegNet: Patient-specific and confounder-aware dysregulated network inference towards precision therapeutics
In: British Journal of Pharmacology (2024)
ISSN: 0007-1188
DOI: 10.1111/bph.17395
URL: https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17395 - , , , , :
Efficiently Labeling and Retrieving Temporal Anomalies in Relational Databases
In: Information Systems Frontiers (2024)
ISSN: 1387-3326
DOI: 10.1007/s10796-024-10495-w - , , , , , :
Emergence of power law distributions in protein-protein interaction networks through study bias
In: eLife 13 (2024), Article No.: e99951
ISSN: 2050-084X
DOI: 10.7554/eLife.99951 - , , :
Federated singular value decomposition for high-dimensional data
In: Data Mining and Knowledge Discovery 38 (2024), p. 938 - 975
ISSN: 1573-756X
DOI: 10.1007/s10618-023-00983-z - , , , , , , :
Inference of differential gene regulatory networks using boosted differential trees
In: Bioinformatics Advances 4 (2024), Article No.: vbae034
ISSN: 2635-0041
DOI: 10.1093/bioadv/vbae034 - , , , , , , :
Spatial cell graph analysis reveals skin tissue organization characteristic for cutaneous T cell lymphoma
In: npj Systems Biology and Applications 10 (2024), Article No.: 143
ISSN: 2056-7189
DOI: 10.1038/s41540-024-00474-x - , , , , , , , , , , , , , , , , , , , , :
ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer
In: EMBO Reports (2024)
ISSN: 1469-221X
DOI: 10.1038/s44319-024-00186-7
Conference Contributions
- , , , , :
Evaluating Machine Learning Models against Clinical Protocols for Enhanced Interpretability and Continuity of Care
First Workshop on Explainable Artificial Intelligence for the Medical Domain (EXPLIMED 2024) (Santiago de Compostela, 20/10/2024 - 20/10/2024)
In: Gianluca Zaza, Gabriella Casalino, Giovanna Castellano (ed.): Proceedings of the First Workshop on Explainable Artificial Intelligence for the Medical Domain (EXPLIMED 2024) co-located with 27th European Conference on Artificial Intelligence (ECAI 2024), Aachen: 2024
Open Access: https://ceur-ws.org/Vol-3831/paper15.pdf
URL: https://ceur-ws.org/Vol-3831/paper15.pdf - , :
Integrating Symbolic Knowledge and Machine Learning in Healthcare
8th International Joint Conference on Rules and Reasoning (Bucharest, 16/09/2024 - 18/09/2024)
In: Anisa Rula, Emanuel Sallinger, Ognjen Savkovic, Ioana Georgiana Ciuciu, Ioan Toma, Josiane Xavier Parreira, Radu Prodan, Hui Song, Ahmet Soylu (ed.): Companion Proceedings of the 8th International Joint Conference on Rules and Reasoning co-located with 20th Reasoning Web Summer School (RW 2024) as part of Declarative AI 2024, Aachen: 2024
Open Access: https://ceur-ws.org/Vol-3816/paper45.pdf
URL: https://ceur-ws.org/Vol-3816/paper45.pdf - , :
Hybrid Personal Medical Digital Assistant Agents
25th Workshop "From Objects to Agents", WOA 2024 (Bard, 08/07/2024 - 10/07/2024)
In: Marco Alderighi, Matteo Baldoni, Cristina Baroglio, Roberto Micalizio, Stefano Tedeschi (ed.): Hybrid Personal Medical Digital Assistant Agents, Aachen: 2024
Open Access: https://ceur-ws.org/Vol-3735/paper_05.pdf
URL: https://ceur-ws.org/Vol-3735/paper_05.pdf - , , :
Symbolic Knowledge Comparison: Metrics and Methodologies for Multi-Agent Systems
25th Workshop “From Objects to Agents” WOA (Bard, 08/07/2024 - 10/07/2024)
In: Marco Alderighi, Matteo Baldoni, Cristina Baroglio, Roberto Micalizio, Stefano Tedeschi (ed.): Proceedings of the 25th Workshop "From Objects to Agents", Aachen: 2024
Open Access: https://ceur-ws.org/Vol-3735/paper_17.pdf
URL: https://ceur-ws.org/Vol-3735/paper_17.pdf - , , , , , , , , , , , , :
Decoil: Reconstructing Extrachromosomal DNA Structural Heterogeneity from Long-Read Sequencing Data
28th International Conference on Research in Computational Molecular Biology, RECOMB 2024 (Cambridge, MA, 29/04/2024 - 02/05/2024)
In: Jian Ma (ed.): Research in Computational Molecular Biology. 28th Annual International Conference, RECOMB 2024, Cambridge, MA, USA, April 29–May 2, 2024, Proceedings, Cham: 2024
DOI: 10.1007/978-1-0716-3989-4_41 - , , , , , , , , , , , , , :
NeDRex-Web: An Interactive Web Tool for Drug Repurposing by Exploring Heterogeneous Molecular Networks
2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024
DOI: 10.1109/BIBM62325.2024.10822390
Journal Articles
- , , , , :
Estimating relative diffusion from 3D micro-CT images using CNNs
In: Artificial Intelligence in Geosciences 4 (2023), p. 199-208
ISSN: 2666-5441
DOI: 10.1016/j.aiig.2023.11.001 - , , , , , , , , , , , , :
Lacking mechanistic disease definitions and corresponding association data hamper progress in network medicine and beyond
In: Nature Communications 14 (2023), Article No.: 1662
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37349-4 - , , , , , , , , , , , :
The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D
In: Acta Neuropathologica Communications 11 (2023), Article No.: 129
ISSN: 2051-5960
DOI: 10.1186/s40478-023-01618-6 - , , , , , , , :
Online bias-aware disease module mining with ROBUST-Web
In: Bioinformatics 35 (2023), Article No.: btad345
ISSN: 1367-4803
DOI: 10.1093/bioinformatics/btad345 - , , , , , , , , , , , , , , :
TF-Prioritizer: a Java pipeline to prioritize condition-specific transcription factors
In: GigaScience 12 (2023), Article No.: giad026
ISSN: 2047-217X
DOI: 10.1093/gigascience/giad026 - , , , , , , , , , , , , :
Performing Automatic Identification and Staging of Urothelial Carcinoma in Bladder Cancer Patients Using a Hybrid Deep-Machine Learning Approach
In: Cancers 15 (2023), Article No.: 1673
ISSN: 2072-6694
DOI: 10.3390/cancers15061673 - , :
Demographic confounders distort inference of gene regulatory and gene co-expression networks in cancer
In: Briefings in Bioinformatics 24 (2023), Article No.: bbad413
ISSN: 1467-5463
DOI: 10.1093/bib/bbad413 - , :
On the role of network topology in German-Jewish recommendation letter networks in the early twentieth century
In: Applied Network Science 8 (2023), Article No.: 24
ISSN: 2364-8228
DOI: 10.1007/s41109-023-00550-x - , :
Privacy of Federated QR Decomposition Using Additive Secure Multiparty Computation
In: IEEE Transactions on Information Forensics and Security 18 (2023), p. 5122-5132
ISSN: 1556-6013
DOI: 10.1109/TIFS.2023.3301710 - , , , :
The edge-preservation similarity for comparing rooted, unordered, node-labeled trees
In: Pattern Recognition Letters 167 (2023), p. 189-195
ISSN: 0167-8655
DOI: 10.1016/j.patrec.2023.02.017
Journal Articles
- , , , :
Online in silico validation of disease and gene sets, clusterings or subnetworks with DIGEST
In: Briefings in Bioinformatics (2022)
ISSN: 1467-5463
DOI: 10.1093/bib/bbac247
URL: https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbac247/6618231?guestAccessKey=e1b9455f-ac28-4d46-af6d-c51b3b98cc8d - , , , :
Enumerating dissimilar minimum cost perfect and error-correcting bipartite matchings for robust data matching
In: Information Sciences 596 (2022), p. 202-221
ISSN: 0020-0255
DOI: 10.1016/j.ins.2022.03.017 - , , , , , , , , :
Privacy-Preserving Artificial Intelligence Techniques in Biomedicine
In: Methods of Information in Medicine (2022)
ISSN: 0026-1270
DOI: 10.1055/s-0041-1740630 - , , , , , , , :
Robust disease module mining via enumeration of diverse prize-collecting Steiner trees
In: Bioinformatics 38 (2022), p. 1600-1606
ISSN: 1367-4803
DOI: 10.1093/bioinformatics/btab876
URL: https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btab876/6497106?guestAccessKey=27c2a19b-11b5-4c3c-88d5-f1131e3809a9
Conference Contributions
- , , , , :
Querying Temporal Anomalies in Healthcare Information Systems and Beyond
26th European Conference on Advances in Databases and Information Systems (ADBIS 2022) (Turin, 05/09/2022 - 08/09/2022)
In: Chiusano S, Cerquitelli T, Wrembel R (ed.): Advances in Databases and Information Systems (ADBIS 2022), Cham: 2022
DOI: 10.1007/978-3-031-15740-0_16
Journal Articles
- , , , , , , , , , , , , , , :
Flimma: a federated and privacy-aware tool for differential gene expression analysis
In: Genome Biology 22 (2021), Article No.: 338
ISSN: 1474-760X
DOI: 10.1186/s13059-021-02553-2 - , , , , , , , , , , , , , , , :
Network medicine for disease module identification and drug repurposing with the NeDRex platform
In: Nature Communications 12 (2021), Article No.: 6848
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27138-2 - , , , :
On the limits of active module identification
In: Briefings in Bioinformatics 22 (2021), Article No.: bbab066
ISSN: 1467-5463
DOI: 10.1093/bib/bbab066
URL: https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbab066/6189770?guestAccessKey=1be406a0-6b26-4e15-b32b-505c1ea2b279 - , , , , , :
Scalable generalized median graph estimation and its manifold use in bioinformatics, clustering, classification, and indexing
In: Information Systems 100 (2021), Article No.: 101766
ISSN: 0306-4379
DOI: 10.1016/j.is.2021.101766 - , , , , , , , , , , , , , , , , , , , , , , , , :
The AIMe registry for artificial intelligence in biomedical research
In: Nature Methods 18 (2021), p. 1128 - 1131
ISSN: 1548-7091
DOI: 10.1038/s41592-021-01241-0
URL: https://rdcu.be/cv5H7 - , , , :
Upper Bounding Graph Edit Distance Based on Rings and Machine Learning
In: International Journal of Pattern Recognition and Artificial Intelligence (2021), Article No.: 2151008
ISSN: 0218-0014
DOI: 10.1142/S0218001421510083
Conference Contributions
- , , , :
On the Privacy of Federated Pipelines
The 44th International ACM SIGIR Conference on Research and Development in Information Retrieval (SIGIR '21) (Virtual Event, 11/07/2021 - 15/07/2021)
In: Proceedings of the 44th International ACM SIGIR Conference on Research and Development in Information Retrieval (SIGIR '21), New York, NY, USA: 2021
DOI: 10.1145/3404835.3462996 - , , , :
Federated Principal Component Analysis for Genome-Wide Association Studies
21st IEEE International Conference on Data Mining (ICDM) (Auckland, New Zealand, 07/12/2021 - 10/12/2021)
In: 21st IEEE International Conference on Data Mining (ICDM) 2021
DOI: 10.1109/ICDM51629.2021.00127 - , , , :
Metric Indexing for Graph Similarity Search
14th International Conference on Similarity Search and Applications (SISAP 2021) (Dortmund, 29/09/2021 - 01/10/2021)
In: Reyes N, Connor R, Kriege N, Kazempour D, Bartolini I, Schubert E, Chen J (ed.): Proceedings of the 14th International Conference on Similarity Search and Applications (SISAP 2021), Cham: 2021
DOI: 10.1007/978-3-030-89657-7_24 - , , , , :
The Minimum Edit Arborescence Problem and Its Use in Compressing Graph Collections
14th International Conference on Similarity Search and Applications (SISAP 2021) (Dortmund, 29/09/2021 - 01/10/2021)
In: Reyes N, Connor R, Kriege N, Kazempour D, Bartolini I, Schubert E, Chen J (ed.): Proceedings of the 14th International Conference on Similarity Search and Applications (SISAP 2021), Cham: 2021
DOI: 10.1007/978-3-030-89657-7_25
Journal Articles
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Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
In: Nature Communications 11 (2020), Article No.: 3518
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17189-2 - , , , , , :
Individuating Possibly Repurposable Drugs and Drug Targets for COVID-19 Treatment through Hypothesis-Driven Systems Medicine Using CoVex
In: Assay and Drug Development Technologies 18 (2020), p. 348-355
ISSN: 1540-658X
DOI: 10.1089/adt.2020.1010 - , , , , , :
EpiGEN: An epistasis simulation pipeline
In: Bioinformatics 36 (2020), p. 4957-4959
ISSN: 1367-4803
DOI: 10.1093/bioinformatics/btaa245
URL: https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaa245/5820008?guestAccessKey=2385c5f1-6587-4065-b2f2-1039765fa5b6 - , , :
What is meaningful research and how should we measure it?
In: Scientometrics 125 (2020), p. 153-169
ISSN: 0138-9130
DOI: 10.1007/s11192-020-03649-5 - , , , , , , , :
BiCoN: Network-constrained biclustering of patients and omics data
In: Bioinformatics 37 (2020), p. 2398 - 2404
ISSN: 1367-4803
DOI: 10.1093/bioinformatics/btaa1076
URL: https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaa1076/6050718?guestAccessKey=e2e9cb2b-ac3d-44a6-abc7-2b92ae15d34c - , , , , :
A framework for modeling epistatic interaction
In: Bioinformatics 37 (2020), p. 1708 - 1716
ISSN: 1367-4803
DOI: 10.1093/bioinformatics/btaa990
URL: https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaa990/6012351?guestAccessKey=4683fb7f-7afc-4b9c-b0d5-3d0085904eb4 - , , , :
Fast linear sum assignment with error-correction and no cost constraints
In: Pattern Recognition Letters 134 (2020), p. 37-45
ISSN: 0167-8655
DOI: 10.1016/j.patrec.2018.03.032 - , :
On the exact computation of the graph edit distance
In: Pattern Recognition Letters 134 (2020), p. 46-57
ISSN: 0167-8655
DOI: 10.1016/j.patrec.2018.05.002 - , , , , :
Comparing heuristics for graph edit distance computation
In: Vldb Journal 29 (2020), p. 419-458
ISSN: 1066-8888
DOI: 10.1007/s00778-019-00544-1 - , , , , :
Finding k-shortest paths with limited overlap
In: Vldb Journal (2020)
ISSN: 1066-8888
DOI: 10.1007/s00778-020-00604-x - , , , :
Improved local search for graph edit distance
In: Pattern Recognition Letters 129 (2020), p. 19-25
ISSN: 0167-8655
DOI: 10.1016/j.patrec.2019.10.028
Journal Articles
- , :
Improved lower bounds for graph edit distance
In: IEEE Transactions on Knowledge and Data Engineering 30 (2018), p. 503-516
ISSN: 1041-4347
DOI: 10.1109/TKDE.2017.2772243
Conference Contributions
- , , , , :
Quasimetric Graph Edit Distance as a Compact Quadratic Assignment Problem
24th International Conference on Pattern Recognition, ICPR 2018 (Beijing, 20/08/2018 - 24/08/2018)
In: Proceedings - International Conference on Pattern Recognition 2018
DOI: 10.1109/ICPR.2018.8546055 - , , , , :
Finding k-dissimilar paths with minimum collective length
26th ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems, ACM SIGSPATIAL GIS 2018 (Seattle, WA, 06/11/2018 - 09/11/2018)
In: Li Xiong, Roberto Tamassia, Kashani Farnoush Banaei, Ralf Hartmut Guting, Erik Hoel (ed.): GIS: Proceedings of the ACM International Symposium on Advances in Geographic Information Systems 2018
DOI: 10.1145/3274895.3274903 - , , , :
Ring based approximation of graph edit distance
Joint IAPR International Workshops on Structural and Syntactic Pattern Recognition, SSPR 2018 and Statistical Techniques in Pattern Recognition, SPR 2018 (Beijing, 17/08/2018 - 19/08/2018)
In: Edwin R. Hancock, Tin Kam Ho, Battista Biggio, Richard C. Wilson, Antonio Robles-Kelly, Xiao Bai (ed.): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2018
DOI: 10.1007/978-3-319-97785-0_28
Conference Contributions
- , :
Correcting and speeding-up bounds for non-uniform graph edit distance
33rd IEEE International Conference on Data Engineering, ICDE 2017 (San Diego, CA, 19/04/2017 - 22/04/2017)
In: Proceedings - International Conference on Data Engineering 2017
DOI: 10.1109/ICDE.2017.57 - , :
Exact computation of graph edit distance for uniform and non-uniform metric edit costs
11th IAPR-TC-15 International Workshop on Graph-Based Representations in Pattern Recognition, GbRPR 2017 (Anacapri, ITA, 16/05/2017 - 18/05/2017)
In: Pasquale Foggia, Mario Vento, Cheng-Lin Liu (ed.): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2017
DOI: 10.1007/978-3-319-58961-9_19